The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

Nat Rev Genet. 2010 Nov;11(11):761-72. doi: 10.1038/nrg2901. Epub 2010 Oct 13.

Abstract

The Mediator is an evolutionarily conserved, multiprotein complex that is a key regulator of protein-coding genes. In metazoan cells, multiple pathways that are responsible for homeostasis, cell growth and differentiation converge on the Mediator through transcriptional activators and repressors that target one or more of the almost 30 subunits of this complex. Besides interacting directly with RNA polymerase II, Mediator has multiple functions and can interact with and coordinate the action of numerous other co-activators and co-repressors, including those acting at the level of chromatin. These interactions ultimately allow the Mediator to deliver outputs that range from maximal activation of genes to modulation of basal transcription to long-term epigenetic silencing.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Growth and Development / genetics
  • Growth and Development / physiology
  • Humans
  • Mediator Complex / chemistry
  • Mediator Complex / metabolism
  • Mediator Complex / physiology*
  • Models, Biological
  • Signal Transduction / physiology
  • Systems Integration
  • Trans-Activators / metabolism
  • Trans-Activators / physiology
  • Transcription, Genetic* / physiology

Substances

  • Mediator Complex
  • Trans-Activators