The Nox/Ferric reductase/Ferric reductase-like families of Eumycetes

Fungal Biol. 2010 Sep;114(9):766-77. doi: 10.1016/j.funbio.2010.07.002. Epub 2010 Jul 14.

Abstract

Reactive Oxygen Species (ROS) are involved in plant biomass degradation by fungi and development of fungal structures. While the ROS-generating NADPH oxidases from filamentous fungi are under strong scrutiny, much less is known about the related integral Membrane (or Ferric) Reductases (IMRs). Here, we present a survey of these enzymes in 29 fungal genomes covering the entire available range of fungal diversity. IMRs are present in all fungal genomes. They can be classified into at least 24 families, underscoring the high diversity of these enzymes. Some are differentially regulated during colony or fruiting body development, as well as by the nature of the carbon source of the growth medium. Importantly, functional characterization of IMRs has been made on proteins belonging to only two families, while nothing or very little is known about the proteins of the other 22 families.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • FMN Reductase / genetics*
  • FMN Reductase / metabolism
  • Fungal Proteins / genetics*
  • Fungal Proteins / metabolism
  • Fungi / classification
  • Fungi / enzymology*
  • Fungi / genetics
  • Genome, Fungal
  • Molecular Sequence Data
  • Multigene Family*
  • NADPH Oxidases / genetics*
  • NADPH Oxidases / metabolism
  • Phylogeny

Substances

  • Fungal Proteins
  • FMN Reductase
  • NADPH Oxidases
  • ferric citrate iron reductase