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. 2010 Nov;10(11):803-8.
doi: 10.1038/nrc2946. Epub 2010 Oct 14.

The Genesis and Evolution of High-Grade Serous Ovarian Cancer


The Genesis and Evolution of High-Grade Serous Ovarian Cancer

David D L Bowtell. Nat Rev Cancer. .


Germline mutation in either BRCA1 or BRCA2 is associated with an increased risk of ovarian cancer, particularly the most common invasive histotype - serous carcinoma. In addition, serous ovarian cancers have an unusually high frequency of other molecular events involving BRCA pathway dysfunction. Recent findings show a high frequency of TP53 mutation, chromosomal instability, distinct molecular subtypes and DNA copy number-driven changes in gene expression. These findings suggest a model in which homologous recombination repair deficiency initiates a cascade of molecular events that sculpt the evolution of high-grade serous ovarian cancer and dictate its response to therapy.

Comment in

  • The forgotten fallopian tube.
    Dietl J, Wischhusen J. Dietl J, et al. Nat Rev Cancer. 2011 Mar;11(3):227; author reply 227. doi: 10.1038/nrc2946-c1. Nat Rev Cancer. 2011. PMID: 21326326 No abstract available.

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