Safety assessment of a calcium-potassium salt of (-)-hydroxycitric acid

Toxicol Mech Methods. 2010 Nov;20(9):515-25. doi: 10.3109/15376516.2010.521207. Epub 2010 Oct 14.


The safety of Garcinia cambogiaextract, its active ingredient (-)-hydroxycitric acid (HCA), and the marketed weight management formula, Super CitriMax(®) (HCA-SX), is supported by numerous in vitro and animal experimental studies as well as several clinical studies. HCA-SX has been shown to reduce appetite, inhibit fat synthesis, and decrease body weight. A series of toxicological tests including acute, short-term, and sub-chronic studies as well as teratogenicity/reproduction and genotoxicity studies were performed on HCA-SX. In the acute oral toxicity study, administration of a single dose of 5,000 mg/kg of HCA-SX did not reveal any significant changes for all examined tissues. Following the high dose safety testing, there were no remarkable changes or differences observed in any of the experimental conditions monitored. There were no macroscopic abnormalities for any examined tissues at scheduled necropsies. On the basis of these findings, the consumption of HCA-SX at dose level of up to 4667 mg/day is considered safe.

Publication types

  • Review

MeSH terms

  • Animals
  • Citrates / toxicity*
  • Dose-Response Relationship, Drug
  • Drug Combinations
  • Female
  • Gene Expression / drug effects
  • Humans
  • Liver / drug effects
  • Male
  • Mutagens / toxicity*
  • Protein Kinase Inhibitors / toxicity*
  • Rabbits
  • Rats
  • Rats, Sprague-Dawley
  • Risk Assessment
  • Salmonella typhimurium / drug effects
  • Toxicity Tests


  • Citrates
  • Drug Combinations
  • Mutagens
  • Protein Kinase Inhibitors
  • Super Citrimax
  • hydroxycitric acid