Emerging role of ISG15 in antiviral immunity

Cell. 2010 Oct 15;143(2):187-90. doi: 10.1016/j.cell.2010.09.033.


Cells express a plethora of interferon-stimulated genes (ISGs) in response to viral infection. Among these is ISG15, a ubiquitin-like protein (UBL) that can be covalently attached to both host and viral proteins. Here we review recent advances toward understanding the role and mechanism of ISG15 modification in antiviral defense.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytokines / immunology*
  • Humans
  • Mice
  • Ubiquitins / immunology*
  • Virus Diseases / immunology*
  • Viruses / immunology*


  • Cytokines
  • G1p2 protein, mouse
  • Ubiquitins
  • ISG15 protein, human