[A case of submandibular gland cancer in elderly patients showed significant effect by S-1 and intravenous docetaxel chemotherapy concurrent with radiotherapy]

Gan To Kagaku Ryoho. 2010 Oct;37(10):1937-40.
[Article in Japanese]


An elderly case of with advanced head and neck cancer treated by intravenous infusion chemotherapy with weekly docetaxel( DOC)and concurrent radiotherapy was reported. The patient was a 77-year-old man. Clinical diagnosis was submandibular gland carcinoma. He was treated by intravenous infusion chemotherapy with weekly DOC and concurrent radiotherapy (total dose 66 Gy). Two months after irradiation, PET-CT showed a partial response (PR). Therefore, chemotherapy of S-1 (80 mg/day) for 2 weeks every 3 weeks was performed. Two months after the end of chemotherapy, PET-CT showed a complete response(CR). This therapy is effective for the treatment of advanced head and neck cancers for elderly inoperable patients.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Biopsy
  • Combined Modality Therapy
  • Docetaxel
  • Drug Combinations
  • Humans
  • Infusions, Intravenous
  • Male
  • Oxonic Acid / administration & dosage
  • Oxonic Acid / therapeutic use*
  • Positron-Emission Tomography
  • Submandibular Gland Neoplasms / drug therapy*
  • Submandibular Gland Neoplasms / pathology
  • Submandibular Gland Neoplasms / radiotherapy
  • Taxoids / administration & dosage
  • Taxoids / therapeutic use*
  • Tegafur / administration & dosage
  • Tegafur / therapeutic use*
  • Tomography, X-Ray Computed


  • Drug Combinations
  • Taxoids
  • S 1 (combination)
  • Tegafur
  • Docetaxel
  • Oxonic Acid