Intervention in at-risk states for developing psychosis

Eur Arch Psychiatry Clin Neurosci. 2010 Nov:260 Suppl 2:S90-4. doi: 10.1007/s00406-010-0139-5. Epub 2010 Oct 14.


Indicated prevention is currently one of the most promising approaches to fight the individual and societal burden associated with psychosis and particularly schizophrenia. The number of studies is still limited, yet encouraging results have been reported from pharmacological and psychotherapeutic trials. Furthermore, it has become clear that persons characterized by the at-risk criteria are already ill and do not only need preventive intervention but also treatment. As is indicated by a recent study successfully using omega-3 fatty acids for both purposes, it may be promising to develop and investigate interventions especially for the at-risk state, independent of their effectiveness in manifest disease states. An overview on the current findings and ongoing research in this area is provided.

Publication types

  • Review

MeSH terms

  • Antipsychotic Agents / therapeutic use*
  • Fatty Acids, Omega-3 / therapeutic use*
  • Humans
  • Mental Disorders / drug therapy
  • Mental Disorders / therapy*
  • Psychotherapy / methods*
  • Randomized Controlled Trials as Topic
  • Risk Factors


  • Antipsychotic Agents
  • Fatty Acids, Omega-3