Repairing injured peripheral nerves: Bridging the gap

Prog Neurobiol. 2010 Nov;92(3):245-76. doi: 10.1016/j.pneurobio.2010.10.002. Epub 2010 Oct 13.


Peripheral nerve injuries that induce gaps larger than 1-2 cm require bridging strategies for repair. Autologous nerve grafts are still the gold standard for such interventions, although alternative treatments, as well as treatments to improve the therapeutic efficacy of autologous nerve grafting are generating increasing interest. Investigations are still mostly experimental, although some clinical studies have been undertaken. In this review, we aim to describe the developments in bridging technology which aim to replace the autograft. A multi-disciplinary approach is of utmost importance to develop and optimise treatments of the most challenging peripheral nerve injuries.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biocompatible Materials
  • Humans
  • Implants, Experimental
  • Intercellular Signaling Peptides and Proteins / pharmacology
  • Nerve Regeneration / physiology*
  • Peripheral Nerve Injuries*
  • Peripheral Nerves / drug effects
  • Peripheral Nerves / pathology
  • Peripheral Nerves / physiopathology
  • Peripheral Nervous System Diseases / pathology*
  • Peripheral Nervous System Diseases / physiopathology
  • Peripheral Nervous System Diseases / therapy*
  • Tissue Scaffolds / chemistry
  • Transplantation, Autologous
  • Transplants
  • Wound Healing


  • Biocompatible Materials
  • Intercellular Signaling Peptides and Proteins