Regulation of sodium channel activity by phosphorylation

Semin Cell Dev Biol. 2011 Apr;22(2):160-5. doi: 10.1016/j.semcdb.2010.10.002. Epub 2010 Oct 13.


Voltage-gated sodium channels carry the major inward current responsible for action potential depolarization in excitable cells as well as providing additional inward current that modulates overall excitability. Both their expression and function is under tight control of protein phosphorylation by specific kinases and phosphatases and this control is particular to each type of sodium channel. This article examines the impact and mechanism of phosphorylation for isoforms where it has been studied in detail in an attempt to delineate common features as well as differences.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Humans
  • Phosphorylation
  • Protein Folding
  • Protein Isoforms / metabolism
  • Protein Subunits / metabolism
  • Sodium Channels / metabolism*


  • Protein Isoforms
  • Protein Subunits
  • Sodium Channels