Association analyses identify six new psoriasis susceptibility loci in the Chinese population

Nat Genet. 2010 Nov;42(11):1005-9. doi: 10.1038/ng.690. Epub 2010 Oct 17.

Abstract

We extended our previous genome-wide association study for psoriasis with a multistage replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from China as well as 3,293 cases and 4,188 controls from Germany and the United States and 254 nuclear families from the United States. We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 × 10⁻⁸) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 × 10⁻²¹) in the European studies. Two of these loci showed evidence for association in the German study at ZNF816A and GJB2 with P = 3.6 × 10⁻³ and P = 7.9 × 10⁻³, respectively. ERAP1 and ZNF816A were associated with type 1 (early onset) psoriasis in the Chinese Han population (test for heterogeneity P = 6.5 × 10⁻³ and P = 1.5 × 10⁻³, respectively). Comparisons with the results of previous GWAS of psoriasis highlight the heterogeneity of disease susceptibility between the Chinese and European populations. Our study identifies new genetic susceptibility factors and suggests new biological pathways in psoriasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aminopeptidases / genetics
  • Asian Continental Ancestry Group / genetics*
  • Connexin 26
  • Connexins / genetics
  • DNA Replication
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study*
  • Germany / epidemiology
  • Humans
  • Membrane Proteins / genetics
  • Minor Histocompatibility Antigens
  • Neoplasm Proteins / genetics
  • Polymorphism, Single Nucleotide*
  • Psoriasis / genetics*
  • Securin
  • Serpins / genetics
  • Tumor Suppressor Proteins
  • United States / epidemiology

Substances

  • CSMD1 protein, human
  • Connexins
  • GJB2 protein, human
  • Membrane Proteins
  • Minor Histocompatibility Antigens
  • Neoplasm Proteins
  • SERPINB8 protein, human
  • Securin
  • Serpins
  • Tumor Suppressor Proteins
  • pituitary tumor-transforming protein 1, human
  • Connexin 26
  • Aminopeptidases
  • ERAP1 protein, human