Steroid receptor coactivator (SRC) family: masters of systems biology

J Biol Chem. 2010 Dec 10;285(50):38743-50. doi: 10.1074/jbc.R110.193367. Epub 2010 Oct 18.


The three members of the p160 family of steroid receptor coactivators (SRC-1, SRC-2, and SRC-3) steer the functional output of numerous genetic programs and serve as pleiotropic rheostats for diverse physiological processes. Since their discovery ∼15 years ago, the extraordinary sum of examination of SRC function has shaped the foundation of our knowledge for the now 350+ coregulators that have been identified to date. In this perspective, we retrace our steps into the field of coregulators and provide a summary of selected seminal work that helped define the SRCs as masters of systems biology.

Publication types

  • Review

MeSH terms

  • Animals
  • Bibliometrics
  • Biomarkers
  • Humans
  • Ligands
  • Models, Biological
  • Models, Genetic
  • Neoplasms / metabolism
  • Nuclear Receptor Coactivator 1 / metabolism*
  • Nuclear Receptor Coactivator 2 / metabolism*
  • Nuclear Receptor Coactivator 3 / metabolism*
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Systems Biology
  • Transcription, Genetic


  • Biomarkers
  • Ligands
  • Nuclear Receptor Coactivator 2
  • Receptors, Cytoplasmic and Nuclear
  • Nuclear Receptor Coactivator 1
  • Nuclear Receptor Coactivator 3