Antigen-driven T-cell repertoire selection during adaptive immune responses

Immunol Cell Biol. 2011 Jan;89(1):54-9. doi: 10.1038/icb.2010.117. Epub 2010 Oct 19.


Protective immunity against a variety of infections depends on the amplification and differentiation of rare naïve antigen-specific CD4 and CD8 T cells. Recent evidence indicates that the clonotypic composition of the responding T-cell compartment has a critical role in the immune defense against pathogens. The present review compares and contrasts how naive CD4 and CD8 T cells recognize their cognate antigen, and discusses the factors that regulate the genesis and maintenance of the CD4 and CD8 T-cell receptor repertoire diversity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity / immunology*
  • Animals
  • Antigen Presentation / immunology
  • Antigens / immunology*
  • Clonal Deletion / immunology
  • Humans
  • Lymphoid Tissue / cytology
  • Lymphoid Tissue / immunology
  • Major Histocompatibility Complex / immunology
  • Receptors, Antigen, T-Cell / immunology
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*


  • Antigens
  • Receptors, Antigen, T-Cell