A preliminary randomized controlled trial of a nurse-delivered medication adherence intervention among HIV-positive outpatients initiating antiretroviral therapy in Beijing, China

AIDS Behav. 2011 Jul;15(5):919-29. doi: 10.1007/s10461-010-9828-3.


We evaluated a nurse-delivered adherence intervention in a preliminary randomized controlled trial among 70 HIV-positive outpatients initiating antiretroviral therapy (ART) in Beijing, China. In both arms, participants received a 30-min educational session, a pillbox, and a referral to a peer support group. In the enhanced arm, participants could choose an electronic reminder device, three sessions of counseling either alone or with a treatment adherence partner, or both reminder and counseling. Survey assessments and blood draws occurred at baseline, post-intervention (13 weeks), and follow-up (25 weeks). Primary outcomes were 7-day and 30-day adherence assessed by self-report and electronic drug monitoring (EDM), and secondary outcomes were HIV-1 RNA viral load and CD4 count. The intervention was feasible and well received. It led to some improvement in self-reported and EDM-assessed adherence but not the biological outcomes. Providing counseling and facilitating the use of electronic reminders to patients initiating ART merits further investigation as a culturally viable means of promoting adherence in China.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Anti-HIV Agents / administration & dosage
  • Anti-HIV Agents / therapeutic use
  • CD4 Lymphocyte Count
  • China
  • Counseling*
  • Cross-Sectional Studies
  • Drug Monitoring / methods*
  • Electronics, Medical
  • Female
  • HIV Infections / drug therapy*
  • HIV Infections / psychology*
  • HIV Infections / virology
  • HIV-1 / drug effects
  • Humans
  • Male
  • Medication Adherence / statistics & numerical data*
  • Middle Aged
  • Nurses*
  • Outpatients
  • RNA, Viral / blood
  • Treatment Outcome
  • Viral Load
  • Young Adult


  • Anti-HIV Agents
  • RNA, Viral