Dietary acrylamide intake and risk of breast cancer in the UK women's cohort

Br J Cancer. 2010 Nov 23;103(11):1749-54. doi: 10.1038/sj.bjc.6605956. Epub 2010 Oct 19.

Abstract

Background: No studies to date have demonstrated a clear association with breast cancer risk and dietary exposure to acrylamide.

Methods: A 217-item food frequency questionnaire was used to estimate dietary acrylamide intake in 33,731 women aged 35-69 years from the UK Women's Cohort Study followed up for a median of 11 years.

Results: In all, 1084 incident breast cancers occurred during follow-up. There was no evidence of an overall association between acrylamide intake and breast cancer (hazard ratio=1.08 per 10 μg day(-1), 95% CI: 0.98-1.18, P(trend)=0.1). There was a suggestion of a possible weak positive association between dietary acrylamide intake and premenopausal breast cancer after adjustment for potential confounders (hazard ratio=1.2, 95% CI: 1.0-1.3, P(trend)=0.008). There was no suggestion of any association for postmenopausal breast cancer (hazard ratio=1.0, 95% CI: 0.9-1.1, P(trend)=0.99).

Conclusions: There is no evidence of an association between dietary acrylamide intake and breast cancer. A weak association may exist with premenopausal breast cancer, but requires further investigation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylamide / administration & dosage
  • Acrylamide / adverse effects*
  • Adult
  • Aged
  • Breast Neoplasms / chemically induced*
  • Cohort Studies
  • Diet
  • Female
  • Humans
  • Middle Aged
  • Prospective Studies
  • Risk
  • United Kingdom

Substances

  • Acrylamide