The Flow Synthesis of Heterocycles for Natural Product and Medicinal Chemistry Applications

Mol Divers. 2011 Aug;15(3):613-30. doi: 10.1007/s11030-010-9282-1. Epub 2010 Oct 20.


This article represents an overview of recent research from the Innovative Technology Centre in the field of flow chemistry which was presented at the FROST2 meeting in Budapest in October 2009. After a short introduction of this rapidly expanding field, we discuss some of our results with a main focus on the synthesis of heterocyclic compounds which we use in various natural product and medicinal chemistry programmes.

MeSH terms

  • Azides / chemistry
  • Biological Products / chemical synthesis
  • Catalysis
  • Chemistry / instrumentation
  • Chemistry / methods*
  • Chemistry, Pharmaceutical / instrumentation
  • Chemistry, Pharmaceutical / methods*
  • Combinatorial Chemistry Techniques / methods*
  • Heterocyclic Compounds / chemical synthesis*
  • Heterocyclic Compounds / chemistry
  • Technology, Pharmaceutical / instrumentation
  • Technology, Pharmaceutical / methods*


  • Azides
  • Biological Products
  • Heterocyclic Compounds