Effect of loss of regional fat assessed by DXA on insulin resistance and dyslipidaemia in obese men

Scand J Clin Lab Invest. 2010 Dec;70(8):547-53. doi: 10.3109/00365513.2010.525660. Epub 2010 Oct 20.


Objective: To investigate the impact of reduction in total fat mass (FM) and regional FMs on indices of insulin resistance and dyslipidaemia in obese men (BMI > 30 kg/m²) after a 1-year weight loss (WL), and secondly, to examine the potential predictive effect of baseline insulin resistance on reduction in total and regional FMs.

Material and methods: In nine men with WL > 4 kg, body composition by DXA (dual X-ray absorptiometry) and indices of insulin resistance were assessed: fasting insulin, C-Peptide and HOMA-IR. Insulin sensitivity (QUICKI) and serum lipids were also assessed.

Results: Mean WL was 10.8%; Δ trunk and Δ leg FM were reduced by 30.1% and 21.3%, respectively, increasing leg/trunk FM ratio by 13.2%. Improvement in HOMA-IR was 63.1%, insulin 59.1%, and in QUICKI 17.4%. Loss of total FM, trunk FM, and increase in leg/trunk FM ratio were correlated with improvement in HOMA-IR (p < 0.001-0.05). Linear regression analysis of ln-transformed improvements in HOMA-IR was non-significantly related with losses of trunk FM and increases in leg/trunk FM ratio (p = 0.06). Multivariate analysis suggested improvements in fasting insulin and C-Peptide could be explained by leg/trunk FM ratio (R² = 0.60, p = 0.013, R² = 0.37, p = 0.012, respectively) and in HOMA-IR by trunk FM (R² = 0.42, p = 0.06). The loss of FM and change in FM distribution had no effect on serum lipids.

Conclusion: Both loss of trunk FM and increase in leg/trunk FM ratio assessed by DXA contribute to the improvement in insulin resistance.

MeSH terms

  • Absorptiometry, Photon*
  • Adipose Tissue / diagnostic imaging*
  • Adult
  • Body Composition
  • Dyslipidemias / blood
  • Dyslipidemias / complications*
  • Dyslipidemias / diagnostic imaging
  • Dyslipidemias / physiopathology*
  • Humans
  • Insulin Resistance / physiology*
  • Lipids / blood
  • Male
  • Middle Aged
  • Obesity / complications*
  • Obesity / diagnostic imaging
  • Obesity / metabolism
  • Obesity / physiopathology
  • Organ Specificity
  • Regression Analysis
  • Weight Loss / physiology*


  • Lipids