Glucose metabolism parameters during an oral glucose tolerance test in patients with autosomal dominant polycystic kidney disease

Scand J Clin Lab Invest. 2010 Dec;70(8):561-7. doi: 10.3109/00365513.2010.527012. Epub 2010 Oct 20.

Abstract

Objective: The aim of the study was to estimate the pancreatic beta cell function and insulin resistance indexes in a group of Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients with normal kidney function and no previous diabetes mellitus diagnosis.

Methods: A total of 49 adult patients with ADPKD aged 36 ± 11 years, and 50 healthy controls, all of Caucasian origin, were included in the study. Blood glucose, insulin and C-peptide concentrations were measured during an oral glucose tolerance test (OGTT with 75 g glucose) performed according to WHO recommendations in all subjects.

Results: The insulin/glucose ratio at the 30th and 120th minute of the OGTT and the insulinogenic index [(insulin at 30 min - insulin at 0 min)/glucose at 30 min] were significantly lower (p = 0.018, p = 0.031 and p = 0.013, respectively) in the ADPKD group. Four other indexes of beta cell function were lower with the borderline statistical significance (p = 0.054-0.076) than in controls. None of the calculated insulin sensitivity indexes differed between the study and control groups.

Conclusions: Presence of ADPKD in patients with normal kidney function is associated with impaired beta cell function after an oral glucose load, without a significant decrease in insulin sensitivity.

MeSH terms

  • Adolescent
  • Adult
  • Anthropometry
  • Case-Control Studies
  • Female
  • Glucose / metabolism*
  • Glucose Tolerance Test / methods*
  • Humans
  • Insulin / blood
  • Insulin-Secreting Cells / metabolism
  • Male
  • Middle Aged
  • Polycystic Kidney, Autosomal Dominant / blood
  • Polycystic Kidney, Autosomal Dominant / metabolism*
  • Young Adult

Substances

  • Insulin
  • Glucose