Comment on: role of changes in the L3 loop of the active site in the evolution of enzymatic activity of VIM-type metallo-β-lactamases

J Antimicrob Chemother. 2011 Mar;66(3):684-5; author reply 686. doi: 10.1093/jac/dkq393. Epub 2010 Oct 20.
No abstract available

Publication types

  • Comment
  • Letter

MeSH terms

  • Adolescent
  • Amino Acid Substitution / genetics
  • Anti-Bacterial Agents / metabolism
  • Anti-Bacterial Agents / pharmacology
  • Carbapenems / metabolism*
  • Carbapenems / pharmacology
  • Catalytic Domain*
  • Enterobacter cloacae / drug effects
  • Enterobacter cloacae / isolation & purification
  • Enterobacteriaceae Infections / microbiology
  • Escherichia coli / drug effects
  • Escherichia coli / isolation & purification
  • Evolution, Molecular*
  • Humans
  • Male
  • Mexico
  • Microbial Sensitivity Tests
  • Mutant Proteins / genetics
  • Mutant Proteins / metabolism
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • Mutant Proteins
  • beta-Lactamases