High-throughput injection with microfluidics using picoinjectors

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19163-6. doi: 10.1073/pnas.1006888107. Epub 2010 Oct 20.


Adding reagents to drops is one of the most important functions in droplet-based microfluidic systems; however, a robust technique to accomplish this does not exist. Here, we introduce the picoinjector, a robust device to add controlled volumes of reagent using electro-microfluidics at kilohertz rates. It can also perform multiple injections for serial and combinatorial additions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Combinatorial Chemistry Techniques
  • High-Throughput Screening Assays / methods*
  • Indicators and Reagents
  • Injections
  • Microfluidic Analytical Techniques / methods*


  • Indicators and Reagents