Maraviroc does not affect humoral response to the pandemic influenza A-H1N1v 2009 adjuvanted vaccine in HIV-1-infected patients

AIDS. 2010 Nov 27;24(18):2887-9. doi: 10.1097/QAD.0b013e3283402bc1.

Abstract

Immune changes induced by the CCR5 antagonist maraviroc raise the question of an impairment of responses to vaccines. We evaluated the immunogenicity of the adjuvanted pandemic influenza A-H1N1v 2009 vaccine in HIV-1-infected patients with suppressed HIV viremia with or without a maraviroc-containing regimen. Seroprotection, seroconversion, and geometric mean titer ratio of specific antibody titers did not differ between groups. These results suggest that maraviroc does not significantly affect the immune response to this adjuvanted vaccine.

MeSH terms

  • Adult
  • Aged
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Cyclohexanes / pharmacology*
  • Disease Outbreaks
  • Female
  • HIV Infections / complications
  • HIV Infections / drug therapy
  • HIV Infections / immunology*
  • HIV-1*
  • Humans
  • Influenza A Virus, H1N1 Subtype / drug effects
  • Influenza A Virus, H1N1 Subtype / immunology*
  • Influenza Vaccines / pharmacology*
  • Influenza, Human
  • Male
  • Maraviroc
  • Middle Aged
  • Triazoles / pharmacology*

Substances

  • Cyclohexanes
  • Influenza Vaccines
  • Triazoles
  • Maraviroc