Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function

Arch Biochem Biophys. 2011 Jan 15;505(2):144-54. doi: 10.1016/ Epub 2010 Oct 18.


Troponin-mediated Ca²(+)-regulation governs the actin-activated myosin motor function which powers striated (skeletal and cardiac) muscle contraction. This review focuses on the structure-function relationship of troponin T, one of the three protein subunits of the troponin complex. Molecular evolution, gene regulation, alternative RNA splicing, and posttranslational modifications of troponin T isoforms in skeletal and cardiac muscles are summarized with emphases on recent research progresses. The physiological and pathophysiological significances of the structural diversity and regulation of troponin T are discussed for impacts on striated muscle function and adaptation in health and diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Evolution, Molecular*
  • Humans
  • Protein Isoforms / chemistry
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • Protein Processing, Post-Translational*
  • Protein Structure, Tertiary
  • Species Specificity
  • Troponin T / chemistry*
  • Troponin T / genetics
  • Troponin T / metabolism*


  • Protein Isoforms
  • Troponin T