Usefulness of glycated albumin as an indicator of glycemic control status in patients with hemolytic anemia

Clin Chim Acta. 2011 Jan 30;412(3-4):253-7. doi: 10.1016/j.cca.2010.10.014. Epub 2010 Oct 18.

Abstract

Background: In patients with hemolytic anemia (HA), glycated hemoglobin (HbA(1C)) presents lower values in relation to glycemia because the lifespan of erythrocytes is shortened, whereas glycated albumin (GA) is not affected. In the present study, we examined the usefulness of GA as an indicator of glycemic control status in patients with HA.

Methods: We enrolled 21 patients with HA. A total of 202 patients with type 2 diabetes mellitus (T2DM) without complications were used as controls.

Results: We identified a significant correlation between GA and HbA(1C) in the patients with HA. However, in a comparison between the patients with HA and those with T2DM, the regression line showed a leftward shift in the former group. There was a significant positive correlation between hemoglobin (Hb) and HbA(1C) in the patients with HA (R=0.541, p=0.025), although there was no significant correlation between Hb and GA. There was an inverse correlation between Hb levels and GA/HbA(1C) ratio (R=-0.710, p=0.001). The measured HbA(1C) levels were lower than the HbA(1C) levels estimated from mean plasma glucose levels, whereas the GA/3 levels were close to the estimated HbA(1C) levels.

Conclusions: GA is a useful indicator of glycemic control status in patients with HA.

MeSH terms

  • Anemia, Hemolytic / blood*
  • Biomarkers / blood
  • Blood Glucose / analysis
  • Blood Glucose / metabolism*
  • Female
  • Glycated Hemoglobin / metabolism
  • Glycated Serum Albumin
  • Glycation End Products, Advanced
  • Humans
  • Male
  • Middle Aged
  • Serum Albumin / analysis
  • Serum Albumin / metabolism*

Substances

  • Biomarkers
  • Blood Glucose
  • Glycated Hemoglobin A
  • Glycation End Products, Advanced
  • Serum Albumin
  • hemoglobin A1c protein, human
  • Glycated Serum Albumin