The heat shock response: life on the verge of death

Mol Cell. 2010 Oct 22;40(2):253-66. doi: 10.1016/j.molcel.2010.10.006.


Organisms must survive a variety of stressful conditions, including sudden temperature increases that damage important cellular structures and interfere with essential functions. In response to heat stress, cells activate an ancient signaling pathway leading to the transient expression of heat shock or heat stress proteins (Hsps). Hsps exhibit sophisticated protection mechanisms, and the most conserved Hsps are molecular chaperones that prevent the formation of nonspecific protein aggregates and assist proteins in the acquisition of their native structures. In this Review, we summarize the concepts of the protective Hsp network.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytoskeleton / metabolism
  • Eukaryotic Cells / metabolism*
  • Heat-Shock Proteins / classification
  • Heat-Shock Proteins / metabolism*
  • Heat-Shock Response / physiology*
  • Humans
  • Models, Biological
  • Organelles / metabolism
  • Signal Transduction*


  • Heat-Shock Proteins