Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress

Mol Cell. 2010 Oct 22;40(2):310-22. doi: 10.1016/j.molcel.2010.09.026.

Abstract

The large serine/threonine protein kinase mTOR regulates cellular and organismal homeostasis by coordinating anabolic and catabolic processes with nutrient, energy, and oxygen availability and growth factor signaling. Cells and organisms experience a wide variety of insults that perturb the homeostatic systems governed by mTOR and therefore require appropriate stress responses to allow cells to continue to function. Stress can manifest from an excess or lack of upstream signals or as a result of genetic perturbations in upstream effectors of the pathway. mTOR nucleates two large protein complexes that are important nodes in the pathways that help buffer cells from stresses, and are implicated in the progression of stress-associated phenotypes and diseases, such as aging, tumorigenesis, and diabetes. This review focuses on the key components of the mTOR complex 1 pathway and on how various stresses impinge upon them.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism
  • Animals
  • Food*
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Mechanistic Target of Rapamycin Complex 1
  • Models, Biological
  • Multiprotein Complexes
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Proteins
  • Signal Transduction / physiology*
  • Stress, Physiological / physiology*
  • TOR Serine-Threonine Kinases / metabolism*
  • Transcription Factors / metabolism

Substances

  • Adaptor Proteins, Signal Transducing
  • Intercellular Signaling Peptides and Proteins
  • Multiprotein Complexes
  • Proteins
  • Transcription Factors
  • Phosphatidylinositol 3-Kinases
  • TOR Serine-Threonine Kinases
  • Mechanistic Target of Rapamycin Complex 1