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, 330 (6003), 514-517

SNP Genotyping Defines Complex Gene-Flow Boundaries Among African Malaria Vector Mosquitoes

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SNP Genotyping Defines Complex Gene-Flow Boundaries Among African Malaria Vector Mosquitoes

D E Neafsey et al. Science.

Erratum in

  • Science. 2010 Dec 10;330(6010):1477

Abstract

Mosquitoes in the Anopheles gambiae complex show rapid ecological and behavioral diversification, traits that promote malaria transmission and complicate vector control efforts. A high-density, genome-wide mosquito SNP-genotyping array allowed mapping of genomic differentiation between populations and species that exhibit varying levels of reproductive isolation. Regions near centromeres or within polymorphic inversions exhibited the greatest genetic divergence, but divergence was also observed elsewhere in the genomes. Signals of natural selection within populations were overrepresented among genomic regions that are differentiated between populations, implying that differentiation is often driven by population-specific selective events. Complex genomic differentiation among speciating vector mosquito populations implies that tools for genome-wide monitoring of population structure will prove useful for the advancement of malaria eradication.

Figures

Fig. 1
Fig. 1
Relative local divergence profiles for pairwise comparisons of mosquito populations, represented by z scores (standard deviations) and scaled so that 0 reflects the modal divergence for each comparison. Plots represent average difference in allelic intensity ratios measured over adjacent 50 SNP stepping windows. The colored regions labeled with letters represent chromosomal inversion locations.(A) Divergence between S and Bamako forms of A. gambiae from Mali. (B) Divergence between A. gambiae M-form mosquitoes and S-form mosquitoes from Mali. (C) Divergence between M-form mosquitoes from Cameroon and S-form mosquitoes from Mali. (D) Divergence between A. arabiensis from Burkina Faso and A. gambiae from Mali.
Fig. 2
Fig. 2
PCA plots of the 2La (A), 2Rj (B), 2Rb (C), 2Rc (D), and 2Ru (E) inversion regions. Circled regions indicate groups of mosquitoes homozygous (ii) or heterozygous (i+) for the inversion or homozygous for the wild-type arrangement (++).
Fig. 3
Fig. 3
Profiles of genomic regions subject to recent selective sweeps in M,S, and Bamako forms of A. gambiae. Each point represents the –log P value of a selective sweep for a window of ~20 SNPs. Windows exhibiting significant signals of selection (P < 0.05 after Bonferroni correction) are indicated in red.

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