Clocks not winding down: unravelling circadian networks

Nat Rev Mol Cell Biol. 2010 Nov;11(11):764-76. doi: 10.1038/nrm2995.


An intrinsic clock enables an organism to anticipate environmental changes and use energy sources more efficiently, thereby conferring an adaptive advantage. Having an intrinsic clock to orchestrate rhythms is also important for human health. The use of systems biology approaches has advanced our understanding of mechanistic features of circadian oscillators over the past decade. The field is now in a position to develop a multiscale view of circadian systems, from the molecular level to the intact organism, and to apply this information for the development of new therapeutic strategies or for enhancing agricultural productivity in crops.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Biological Clocks / genetics*
  • CLOCK Proteins / genetics
  • Circadian Rhythm / genetics*
  • Energy Metabolism / genetics*
  • Gene Expression Profiling
  • Gene Regulatory Networks*
  • Humans
  • Models, Genetic


  • CLOCK Proteins