Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors

Immunol Rev. 2010 Nov;238(1):37-46. doi: 10.1111/j.1600-065X.2010.00963.x.


Hematopoietic stem cells (HSCs) continuously replenish all classes of blood cells through a series of lineage restriction steps that results in the progressive loss of differentiation potential to other cell lineages. This review focuses on the recent advances in understanding one of the earliest differentiation steps in HSC maturation, which involves the diversification of the lymphoid and myeloid cell lineages, the two major branches of hematopoietic cells. We discuss progress in the identification and characterization of progenitor populations downstream of HSCs, which has been a key to understanding the sequential biological events that take place along the course of differentiation into a certain hematopoietic cell type. We also discuss the importance of bone marrow microenvironment in lymphoid and myeloid lineage choice.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bone Marrow / growth & development
  • Bone Marrow / immunology
  • Cell Lineage / immunology*
  • Cytokines / immunology
  • Hematopoiesis / immunology*
  • Humans
  • Lymphoid Progenitor Cells / immunology*
  • Multipotent Stem Cells / immunology*
  • Myeloid Progenitor Cells / immunology*


  • Cytokines