Homeopathic Symphytum officinale increases removal torque and radiographic bone density around titanium implants in rats

Homeopathy. 2010 Oct;99(4):249-54. doi: 10.1016/j.homp.2010.08.002.


Introduction: This study evaluated the effect of Symphytum officinale in homeopathic potency (6cH), on the removal torque and radiographic bone density around titanium implants, inserted in rats tibiae.

Methods: Implants were placed in male rat tibiae, and the animals randomized to two groups (Control and S. officinale 6cH treated), which were evaluated at 7, 14, 28 and 56 days post-implantation. Radiographic bone density was measured at 6 points around the implant, using digital radiographic images, when implants were inserted and at sacrifice. Removal torque of the implants was also evaluated.

Results: Both removal torque and radiographic bone density evaluation showed that S. officinale 6cH treatment enhanced bone formation around the micro-implants, mainly at 14 days. At 56 days, the radiographic bone density was higher in the treated group.

Conclusions: We conclude that S. officinale 6cH enhances, principally at the early stages of osseointegration, bone formation around titanium implants in rats' tibiae, based on radiographic and mechanical analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Bone Density / drug effects*
  • Comfrey*
  • Implants, Experimental*
  • Male
  • Osseointegration / drug effects*
  • Plant Exudates / pharmacology*
  • Radiography
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • Tibia / diagnostic imaging
  • Tibia / drug effects
  • Tibia / surgery
  • Titanium*
  • Torque
  • Wound Healing / drug effects*


  • Plant Exudates
  • Titanium