In vitro effects of peroxisome proliferator-activated receptor-γ ligands on gene expression in lipopolysaccharide-induced endometrial and endometriotic stromal cells

Fertil Steril. 2011 Feb;95(2):829-31.e1-5. doi: 10.1016/j.fertnstert.2010.09.008.

Abstract

This in vitro study demonstrates the comparative anti-inflammatory effects of rosiglitazone and 15d-PGJ(2) in endometriosis and provides evidence for exploitation of peroxisome proliferator-activated receptor-γ as a therapeutic target.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents / pharmacology*
  • Biopsy
  • Case-Control Studies
  • Cells, Cultured
  • Drug Evaluation, Preclinical
  • Endometriosis / pathology
  • Endometrium / drug effects*
  • Endometrium / metabolism
  • Endometrium / pathology
  • Endometrium / physiology
  • Female
  • Gene Expression / drug effects*
  • Humans
  • Ligands
  • Lipopolysaccharides / pharmacology*
  • PPAR gamma / agonists*
  • PPAR gamma / genetics
  • PPAR gamma / metabolism
  • Prostaglandin D2 / pharmacology
  • Rosiglitazone
  • Stromal Cells / drug effects*
  • Stromal Cells / metabolism
  • Stromal Cells / pathology
  • Stromal Cells / physiology
  • Thiazolidinediones / pharmacology
  • Uterine Diseases / pathology

Substances

  • Anti-Inflammatory Agents
  • Ligands
  • Lipopolysaccharides
  • PPAR gamma
  • Thiazolidinediones
  • Rosiglitazone
  • Prostaglandin D2