Long-term results of photodynamic therapy for choroidal neovascularization in Japanese patients with pathologic myopia

Am J Ophthalmol. 2011 Jan;151(1):137-147.e1. doi: 10.1016/j.ajo.2010.06.046.


Objective: To determine the results of photodynamic therapy (PDT) in highly myopic eyes with choroidal neovascularization (CNV).

Design: Open-label, consecutive, interventional case series.

Methods: Forty-eight eyes of 46 consecutive Japanese patients with a myopic CNV were studied. The eyes were treated with PDT and were followed up from 1 to 4 years. The best-corrected visual acuities (BCVAs) at the baseline and after the PDT were compared. Multivariate regression analyses were used to determine the factors that were significantly associated with the BCVA at 3 or 4 years.

Results: The mean follow-up period was 3.2 years. Sixty-nine percent of the patients obtained angiographic closure by a single PDT treatment, and the average number of PDT treatments was 1.4. Chorioretinal atrophy developed in 61% of the eyes at 3 years and in 70% of the eyes at 4 years. The BCVA did not change significantly after the PDT. Multivariate regression analyses showed that the BCVA at 3 years was significantly correlated with the baseline BCVA and area of chorioretinal atrophy. Analyses of the 20 patients at 4 years or more showed that in 5 of 7 (71.4%) patients with juxtafoveal CNV, chorioretinal atrophy did not develop and that all had BCVA of 0.5 or better. However, in 12 of the 13 patients with a subfoveal CNV, chorioretinal atrophy developed at 4 years, and 10 of these patients had BCVA of 0.1 or worse.

Conclusions: In highly myopic patients, 69% obtained angiographic closure by a single PDT treatment, and recurrence was rare. These findings indicate that PDT is still a good option for treating CNVs in highly myopic patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Asian People
  • Choroidal Neovascularization / drug therapy*
  • Choroidal Neovascularization / etiology
  • Choroidal Neovascularization / physiopathology
  • Female
  • Fluorescein Angiography
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Myopia, Degenerative / complications
  • Myopia, Degenerative / drug therapy*
  • Myopia, Degenerative / physiopathology
  • Photochemotherapy*
  • Photosensitizing Agents / therapeutic use
  • Prognosis
  • Prospective Studies
  • Visual Acuity / physiology
  • Young Adult


  • Photosensitizing Agents