Very late recurrences of leukemia: why does leukemia awake after many years of dormancy?

Leuk Res. 2011 Feb;35(2):139-44. doi: 10.1016/j.leukres.2010.09.016.


We report a heterogeneous group of very late recurrences of leukemia occurring more than 10 years after initial treatment including 2 cases of childhood acute lymphoblastic leukemia (ALL) which recurred after more than 20 years of remission, 2 cases of donor cell leukemia which developed more than 10 years after allograft for acute myeloid leukemia (AML) and high risk myelodysplastic syndrome (MDS) and 2 cases of chronic myeloid leukemia (CML) relapsing 13 and 17 years after allograft. Case descriptions are followed by a discussion regarding possible mechanisms leading to leukemia recurrence and a review of the literature.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Female
  • Humans
  • Leukemia* / genetics
  • Leukemia* / pathology
  • Leukemia* / therapy
  • Male
  • Middle Aged
  • Neoplasms, Second Primary / genetics
  • Neoplasms, Second Primary / pathology
  • Neoplasms, Second Primary / therapy
  • Recurrence
  • Stem Cell Transplantation