Regulation between survival, persistence, and elimination of intracellular mycobacteria: a nested equilibrium of delicate balances

Microbes Infect. 2011 Feb;13(2):121-33. doi: 10.1016/j.micinf.2010.10.009. Epub 2010 Nov 4.


This review elaborates on recent insights gained on the dynamic aspects of interactions between pathogen and the host intracellular machinery in tuberculosis infection. In addition we will also discuss the utility of adopting a systems biology approach, both for a better understanding of TB biology, and for the development of more effective ways for disease management.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autophagy / physiology
  • Host-Pathogen Interactions*
  • Humans
  • Lipid Metabolism
  • Mycobacterium / immunology
  • Mycobacterium / physiology*
  • Mycobacterium Infections / metabolism
  • Mycobacterium Infections / microbiology*
  • Signal Transduction / genetics