Drug encapsulation within self-assembled microglobules formed by thermoresponsive supramolecules

Chem Commun (Camb). 2010 Dec 7;46(45):8537-9. doi: 10.1039/c0cc04063k. Epub 2010 Oct 25.

Abstract

An 8-(phenyl)-2'-deoxyguanosine derivative self-assembles in aqueous media into discrete hexadecamers that further self-assemble above 32 °C into microglobules that encapsulate the drug doxorubicin.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Deoxyadenosines / chemical synthesis
  • Deoxyadenosines / chemistry
  • Doxorubicin / chemistry*
  • Drug Carriers / chemical synthesis
  • Drug Carriers / chemistry*
  • Magnetic Resonance Spectroscopy
  • Temperature*

Substances

  • 8-phenyl-2'-deoxyguanosine
  • Deoxyadenosines
  • Drug Carriers
  • Doxorubicin