Objective: This article represents a review of the literature, mainly from Russian sources, dealing with the therapeutic application of low-intensity electromagnetic radiation in the millimeter band applied to experimental and clinical oncology.
Method: At the early stage of these studies, efficacy and safety of millimeter electromagnetic radiation (extremely high frequency [EHF]) was proved for various types of malignant tumors. The majority of the further studies demonstrated the high efficacy and safety of millimeter wave radiation in treating patients suffering from both benign and malignant tumors.
Results: Developments led to treatment on skin melanoma, cancer of the ear-nose-throat, bowel and breast cancer, cancer of the uterus, lung, and stomach, solid tumors, as well as lymphoma. The main indications for this therapy are (1) preparation prior to radical treatment; (2) prevention and treatment of side-effects and complications from chemotherapy and radiotherapy; (3) prevention of metastases, relapses, and dissemination of the tumor; (4) treatment of the paraneoplastic syndrome; and (5) palliative therapy of incurable patients.
Conclusions: In spite of the fact that not all mechanisms underlying effects of EHF therapy are known as yet, this therapeutic modality has been shown to have great potential in clinical oncology from studies performed in Eastern Europe and Russia.