Development of a culturally appropriate health-related quality of life measure for human immunodeficiency virus-infected children in Thailand

J Paediatr Child Health. 2011 Jan;47(1-2):27-33. doi: 10.1111/j.1440-1754.2010.01886.x. Epub 2010 Oct 26.


Aim: Develop a reliable and valid self-report health-related quality of life (HRQOL) instrument for human immunodeficiency virus (HIV)-infected children in Thailand.

Methods: The Thai Quality of Life for HIV-infected Children instrument, the ThQLHC (an HRQOL measure that uses the Pediatric Quality of Life Inventory as a generic core and a 17-item HIV-targeted scale), was developed and administered cross-sectionally to 292 HIV-infected children in Thailand. The disease-targeted scale included HIV-related symptoms, ability to adhere with their treatment regimens and self-image. The internal consistency reliability (Cronbach's α) and construct validity of the ThQLHC scales were then evaluated.

Results: Internal consistency reliability coefficients ranged from 0.57 to 0.82, with four of five scales reaching the minimal acceptable level (>0.70). Significant associations were found between poor HRQOL and poor self-rated disease severity, care giver's rated overall quality of life, cluster of differentiation (CD) 4 percent and plasma HIV ribonucleic acid level.

Conclusion: Reliable and valid disease-targeted HRQOL measures for HIV-infected children are essential in the assessment of therapeutic effectiveness. The findings of this cross-sectional survey provide support for the reliability and validity of the ThQLHC as an HRQOL outcome measure for HIV-infected Thai children.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Caregivers / psychology
  • Child
  • Cultural Competency*
  • Female
  • HIV Infections / psychology*
  • Humans
  • Interviews as Topic
  • Male
  • Middle Aged
  • Pediatrics / methods
  • Pediatrics / standards
  • Qualitative Research
  • Regression Analysis
  • Reproducibility of Results
  • Self Report
  • Sickness Impact Profile*
  • Thailand