Handedness and dominant side of symptoms in Parkinson's disease

Parkinsonism Relat Disord. 2011 Jan;17(1):58-60. doi: 10.1016/j.parkreldis.2010.10.002. Epub 2010 Oct 25.


The aim of this retrospective study was to assess the presence of a possible association between handedness and the side of symptom dominance in 963 patients with Parkinson's disease (PD). In only 287 patients the hand dominance was registered. Out of 254 right-handed patients, 158 (62%) had a right-side dominance of PD symptoms, while 96 patients (38%) had left-lateralized symptom dominance (p < 0.001). For the 33 left-handed subjects, 18 (55%) had left- and 15 (45%) had right-sided symptom dominance (p = 0.602). Right-handedness thus appeared to be associated with right-sided dominance of PD symptoms, while the group of left-handed patients was too small to draw conclusions from. Possible explanations are discussed.

MeSH terms

  • Age of Onset
  • Aged
  • Female
  • Functional Laterality / physiology*
  • Gait / physiology
  • Gait Disorders, Neurologic / physiopathology
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / physiopathology*
  • Retrospective Studies