Secondary Syphilis: The Classical Triad of Skin Rash, Mucosal Ulceration and Lymphadenopathy

Int J STD AIDS. 2010 Aug;21(8):537-45. doi: 10.1258/ijsa.2010.010243.


After years of declining incidence in many developed countries, syphilis infection has re-emerged as a major public health problem in the past decade. The secondary stage of syphilis epitomizes the capacity of the infection to present in myriad ways. The skin, lymph glands and mucosal membranes are the most commonly affected tissues.

Publication types

  • Review

MeSH terms

  • Exanthema / etiology
  • Exanthema / pathology*
  • Female
  • Humans
  • Incidence
  • Lymphatic Diseases / etiology
  • Lymphatic Diseases / pathology*
  • Male
  • Mucous Membrane / pathology*
  • Syphilis / diagnosis
  • Syphilis / epidemiology
  • Syphilis / pathology
  • Ulcer / etiology
  • Ulcer / pathology*

Supplementary concepts

  • Syphilis, secondary