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Review
, 5 (6), 463-6

What Are Biomarkers?

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Review

What Are Biomarkers?

Kyle Strimbu et al. Curr Opin HIV AIDS.

Abstract

Purpose of review: This article provides working definitions and a conceptual framework to understand the roles of biomarkers in clinical research.

Recent findings: The definitions of the terms discussed in this article--medical signs, symptoms, biomarkers, surrogate endpoints, clinical endpoints, validation--are still under discussion, as are their relationships to each other, but broad consensus has developed in the past decade and a half about the necessity of distinguishing between, in particular, surrogate and clinical endpoints.

Summary: This article outlines the major definitions of the key terms in this field and considers select cases in which misunderstandings about the terms led to flawed research conclusions.

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