Trans fatty acids, insulin resistance and diabetes

Eur J Clin Nutr. 2011 May;65(5):553-64. doi: 10.1038/ejcn.2010.240. Epub 2010 Oct 27.

Abstract

The possible relationship between consumption of trans fatty acids (TFAs) and risk of insulin resistance or development of diabetes mellitus type II has been considered by a number of human and animal studies over the past decade. This review evaluates the evidence, and concludes that there is limited evidence for a weak association at high TFA intakes, but very little convincing evidence that habitual exposure as part of a standard western diet has a significant contribution to risk of diabetes or insulin resistance. The possibility of increased risk for individuals with particular genotypes (such as the FABP2 Thr54 allele) is of interest, but further work would be required to provide sufficient evidence of any association.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipocytes / drug effects
  • Adipocytes / metabolism
  • Animals
  • Cells, Cultured
  • Chlorocebus aethiops
  • Cohort Studies
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / etiology*
  • Diabetes Mellitus, Type 2 / genetics
  • Dietary Fats / administration & dosage*
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Insulin / metabolism
  • Insulin Resistance*
  • Insulin Secretion
  • Islets of Langerhans / drug effects
  • Islets of Langerhans / metabolism
  • Male
  • Models, Animal
  • Prospective Studies
  • Randomized Controlled Trials as Topic
  • Trans Fatty Acids / administration & dosage
  • Trans Fatty Acids / adverse effects*

Substances

  • Dietary Fats
  • Insulin
  • Trans Fatty Acids