Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells

Arch Dermatol Res. 2011 May;303(4):239-46. doi: 10.1007/s00403-010-1088-6. Epub 2010 Oct 27.


Exposing skin to ultraviolet (UV) radiation contributes to photoaging and to the development of skin cancer by DNA lesions and triggering inflammatory and other harmful cellular cascades. The present study tested the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin. Introducing PFA to keratinocytes prior to their exposure to UVB exerted a protective effect, increasing cell viability, decreasing the secretion of IL-6 and PGE(2), and enhancing DNA repair. In human skin explants, treating with PFA reduced significantly UV-induced cellular damage. These results support the idea that PFA can play an important role as a photo-protective agent in UV-induced skin damage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents
  • Cell Survival / drug effects
  • Cells, Cultured
  • DNA Damage
  • DNA Repair
  • Dinoprostone / metabolism
  • Fatty Alcohols / pharmacology*
  • Humans
  • Inflammation / drug therapy
  • Inflammation / metabolism
  • Interleukin-6 / metabolism
  • Keratinocytes / drug effects*
  • Keratinocytes / radiation effects
  • Organ Culture Techniques
  • Persea / chemistry*
  • Polymerase Chain Reaction
  • Pyrimidine Dimers / analysis
  • Skin / drug effects*
  • Skin / radiation effects
  • Ultraviolet Rays


  • Anti-Inflammatory Agents
  • Fatty Alcohols
  • Interleukin-6
  • Pyrimidine Dimers
  • Dinoprostone