DNA damage response

Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1):a000745. doi: 10.1101/cshperspect.a000745.


Structural changes to DNA severely affect its functions, such as replication and transcription, and play a major role in age-related diseases and cancer. A complicated and entangled network of DNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance processes, and cell-cycle checkpoints safeguard genomic integrity. Like transcription and replication, DDR is a chromatin-associated process that is generally tightly controlled in time and space. As DNA damage can occur at any time on any genomic location, a specialized spatio-temporal orchestration of this defense apparatus is required.

Publication types

  • Review

MeSH terms

  • Animals
  • Chromatin / metabolism*
  • DNA Damage / physiology*
  • DNA Repair / physiology*
  • Genes, cdc / physiology*
  • Genomic Instability / physiology*
  • Histones / metabolism
  • Humans
  • Models, Biological*
  • Phosphorylation
  • Signal Transduction / physiology*


  • Chromatin
  • H2AX protein, human
  • Histones