Allelic interactions at the shibire locus of Drosophila: effects on behavior

J Neurogenet. 1990 Nov;7(1):1-14. doi: 10.3109/01677069009084149.


This report describes a detailed behavioral study of four shi alleles, shits1, shits2, shits4, and shiST139, and their heteroallelic combinations. Flies of different heteroallelic combinations (shi/shi) were less sensitive to high temperature than the corresponding homozygotes. Among them, shits2/shits4 showed a striking reduction in temperature sensitivity. In contrast, different shi/+ heterozygotes were more severe in temperature sensitivity than the hemizygotes, Df/+. The hemizygous combinations of shi alleles over deficiency (shi/Df) were not completely lethal, with shits2 conferring distinctively higher and shits4 lower viability. A novel behavior, bang sensitivity, was also found in shi/Df. The results of allelic interactions suggest that the shi mutations examined appear to be antimorphic and that the shi gene products are likely to function in multimeric form.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles*
  • Animals
  • Behavior, Animal
  • Crosses, Genetic
  • Drosophila / genetics*
  • Drosophila / physiology
  • Genetic Variation / genetics
  • Genotype
  • Heterozygote
  • Homozygote
  • Movement
  • Mutation
  • Nervous System Physiological Phenomena
  • Temperature
  • Vibration
  • X Chromosome