Immunoglobulin G subclass deficiency in children with high levels of immunoglobulin E and infection proneness

Int Arch Allergy Appl Immunol. 1990;93(4):285-8. doi: 10.1159/000235255.


Of 32 unrelated children with serum IgE greater than 1,000 U/ml, 17 were found to have infection proneness according to standard clinical criteria, and 15 were not infection prone. There were no statistical differences between these 2 groups of children with regard to age, sex, serum IgE levels or prevalence of asthma. However, the prevalence of eczema was significantly lower in the infection-prone group (p = 0.035). Of greater interest was the finding that 7 children in the infection-prone group had IgG subclass and/or IgA deficiency compared with none in the non-infection-prone group (p = 0.006). These results suggest that IgG subclass studies may be warranted in children with markedly elevated levels of serum IgE and proneness to infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Asthma / immunology
  • Child
  • Child, Preschool
  • Dysgammaglobulinemia / immunology*
  • Eczema / immunology
  • Female
  • Humans
  • Hypergammaglobulinemia / immunology*
  • IgG Deficiency*
  • Immunoglobulin E / analysis*
  • Male
  • Respiratory Tract Infections / immunology*


  • Immunoglobulin E