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. 2010 Nov 29;73(11):1922-6.
doi: 10.1021/np100588c. Epub 2010 Oct 28.

Pulicatins A-E, Neuroactive Thiazoline Metabolites From Cone Snail-Associated Bacteria

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Free PMC article

Pulicatins A-E, Neuroactive Thiazoline Metabolites From Cone Snail-Associated Bacteria

Zhenjian Lin et al. J Nat Prod. .
Free PMC article

Abstract

The cone snail Conus pulicarius from the Philippines provides a specific habitat for actinomycetes and other bacteria. A phenotypic screen using primary cultures of mouse dorsal root ganglion neurons revealed that one C. pulicarius associate, Streptomyces sp. CP32, produces a series of natural products that enhance or diminish whole-cell Ca(2+) flux. These compounds include known thiazoline compounds and a series of new derivatives, pulicatins A-E (6-10). Individual compounds were shown to bind to a series of human receptors, with selective binding to the human serotonin 5-HT(2B) receptor. Here, we report the structure elucidation of the new compounds and results of the neurological assays.

Figures

Figure 1
Figure 1
Key HMBC, 1H-1H COSY and NOESY Correlations of Compounds 1 and 6-10.
Figure 2
Figure 2
CD Spectra of Compounds 1, 6 and 7.

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