Abstract
Paracetamol toxicity induced in mice a significant depletion in hepatic and renal glutathione concentrations. The administration of CoA in animals prevents the mortality induced by paracetamol and simultaneously prevents the reduction in renal and hepatic glutathione concentrations.
MeSH terms
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Acetaminophen / toxicity*
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Animals
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Coenzyme A / chemistry
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Coenzyme A / pharmacology*
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Dose-Response Relationship, Drug
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Female
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Glutathione / metabolism*
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Kidney / drug effects
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Kidney / metabolism*
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Liver / drug effects
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Liver / metabolism*
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Male
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Rats
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Sulfhydryl Compounds / analysis
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Sulfhydryl Compounds / pharmacology
Substances
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Sulfhydryl Compounds
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Acetaminophen
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Glutathione
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Coenzyme A