Repeatability and reproducibility of anterior ocular biometric measurements with 2-dimensional and 3-dimensional optical coherence tomography

J Cataract Refract Surg. 2010 Nov;36(11):1867-73. doi: 10.1016/j.jcrs.2010.05.024.

Abstract

Purpose: To evaluate the repeatability and reproducibility of central corneal thickness (CCT), anterior chamber depth (ACD), and anterior chamber width (ACW) measurements using 3-dimensional (3-D) corneal and anterior segment optical coherence tomography (CAS-OCT) and 2-dimensional (2-D) anterior segment OCT (AS-OCT).

Setting: Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.

Design: Nonrandomized clinical trial.

Methods: The CCT, ACD, and ACW were measured in normal eyes using a prototype 3-D swept-source CAS-OCT device and a 2-D time-domain AS-OCT device (Visante). The coefficient of repeatability and reproducibility and the intraclass correlation coefficient (ICC) were calculated to evaluate the repeatability and reproducibility of the measurements.

Results: Eighty-five eyes (85 subjects) were evaluated. The mean CCT measurement was 557.5 μm ± 40.5 (SD) with CAS-OCT and 556.4 ± 39.4 μm with AS-OCT; the mean ACD measurement, 3.13 ± 0.40 mm and 3.16 ± 0.39 mm, respectively; and the mean ACW, 11.80 ± 0.47 mm and 11.79 ± 0.49 mm, respectively. There was no statistically significant difference in CCT or ACW measurements between the 2 devices (P>.05, Wilcoxon signed rank test). Although the ACD measurements were significantly different (P<.0001), the difference was small (0.03 mm). Significant linear correlations were found between the measurements of the 2 devices (P<.0001). The ICC was greater than 0.99 for CAS-OCT and greater than 0.96 for AS-OCT.

Conclusion: Corneal and anterior segment OCT and AS-OCT provided comparable and well-correlated anterior ocular biometric measurements, with sufficient repeatability and reproducibility.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anterior Chamber / anatomy & histology*
  • Biometry / methods
  • Cornea / anatomy & histology*
  • Female
  • Humans
  • Imaging, Three-Dimensional
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Tomography, Optical Coherence / instrumentation
  • Tomography, Optical Coherence / methods*
  • Young Adult