Recycling endosomes and TLR signaling--the Rab11 GTPase leads the way

Immunity. 2010 Oct 29;33(4):578-80. doi: 10.1016/j.immuni.2010.10.003.


The ability of Toll-like receptors (TLRs) to activate innate immunity depends on their transport to pathogen-containing organelles. In this issue of Immunity, Husebye et al. (2010) report that delivery of TLR4 to phagosomes occurs via a recycling endosome intermediate, which is controlled by the GTPase Rab11a.

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