Recycling endosomes and TLR signaling--the Rab11 GTPase leads the way

Jonathan C Kagan

doi:10.1016/j.immuni.2010.10.003

Recycling endosomes and TLR signaling--the Rab11 GTPase leads the way

Immunity. 2010 Oct 29;33(4):578-80. doi: 10.1016/j.immuni.2010.10.003.

Author

Jonathan C Kagan¹

Affiliation

¹ Department of Pediatrics, Division of Gastroenterology and Harvard Medical School, Children's Hospital Boston, 300 Longwood Ave, Enders 730.2, Boston, MA 02115, USA. jonathan.kagan@childrens.harvard.edu

PMID: 21029967
DOI: 10.1016/j.immuni.2010.10.003

Abstract

The ability of Toll-like receptors (TLRs) to activate innate immunity depends on their transport to pathogen-containing organelles. In this issue of Immunity, Husebye et al. (2010) report that delivery of TLR4 to phagosomes occurs via a recycling endosome intermediate, which is controlled by the GTPase Rab11a.

Publication types

Comment

Grants and funding

R00 AI072955/AI/NIAID NIH HHS/United States