Functional interactions between nucleoporins and chromatin

Curr Opin Cell Biol. 2011 Feb;23(1):65-70. doi: 10.1016/ Epub 2010 Oct 26.


As the gatekeepers of the eukaryotic cell nucleus, nuclear pore complexes (NPCs) mediate all molecular trafficking between the nucleoplasm and the cytoplasm. In recent years, transport-independent functions of NPC components, nucleoporins, have been identified including roles in chromatin organization and gene regulation. Here, we summarize our current view of the NPC as a dynamic hub for the integration of chromatin regulation and nuclear trafficking and discuss the functional interplay between nucleoporins and the nuclear genome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Active Transport, Cell Nucleus
  • Animals
  • Chromatin / metabolism*
  • Genome / genetics
  • Humans
  • Nuclear Pore Complex Proteins / metabolism*
  • Protein Binding
  • Transcription, Genetic


  • Chromatin
  • Nuclear Pore Complex Proteins