DNAzyme-like activity of hemin-telomeric G-quadruplexes for the optical analysis of telomerase and its inhibitors

Chembiochem. 2010 Nov 22;11(17):2362-7. doi: 10.1002/cbic.201000512.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminobenzoates / pharmacology
  • Base Sequence
  • Biocatalysis / drug effects
  • Cells, Cultured
  • DNA, Catalytic / chemistry
  • DNA, Catalytic / metabolism*
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / pharmacology
  • G-Quadruplexes*
  • HEK293 Cells
  • Hemin / chemistry
  • Hemin / metabolism
  • Humans
  • Kinetics
  • Logistic Models
  • Microscopy, Atomic Force
  • Naphthalenes / pharmacology
  • Spectrophotometry, Ultraviolet
  • Telomerase / antagonists & inhibitors
  • Telomerase / metabolism*
  • Telomere / chemistry
  • Telomere / genetics
  • Telomere / metabolism*
  • Time Factors

Substances

  • Aminobenzoates
  • BIBR 1532
  • DNA, Catalytic
  • Enzyme Inhibitors
  • Naphthalenes
  • Hemin
  • Telomerase