Heart and heart-lung transplantation at the Johns Hopkins Hospital

Clin Transpl. 1990:89-94.

Abstract

Since 1983, 120 patients have undergone heart transplantation and 18 patients have had heart-lung transplants at our institution. Transplantation is limited only by donor referrals but relaxation of donor criteria has increased donor availability. Immunosuppression currently consists of a 3-drug protocol of CsA, Aza, and P. Our current 1- and 5-year survival rates for heart transplants are 85% and 66%, respectively. The 1-year survival for heart-lung transplantation is 53%. Research continues in many areas of transplantation. The development of coronary artery disease in grafted hearts remains a problem. We have found that older donor age and Cmv infection are significant predictors of developing coronary disease. Routine successful extended heart-lung preservation has been difficult to achieve. A successful technique of prolonged preservation would allow for better matching, reduced logistics, and, potentially, increased numbers of donor organs.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Baltimore
  • Follow-Up Studies
  • Graft Rejection
  • Heart Transplantation* / immunology
  • Heart-Lung Transplantation* / immunology
  • Humans
  • Immunosuppression Therapy / methods
  • Tissue Donors
  • Tissue and Organ Procurement